Fenbendazole capsules are compounded specifically for your pet at the direction of your veterinarian. They should be stored in a tightly sealed container at room temperature, and protected from sunlight.
Fenbendazole (Panacur®) is a broad-spectrum benzimidazole with anthelmintic activity against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms (except Dipylidium caninum, the common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles and Strongyloides. It is approved for administration under veterinary prescription to sheep, cattle, horses, fish, dogs, cats, rabbits and seals.
It blocks microtubule production in parasite cells to kill them. It is safe in the body and is excreted after 48 hours. In addition, it is also effective in a wide range of intestinal parasites that are resistant to other medications. It is a popular choice for the treatment of Giardia in dogs and lungworms in cats.
Studies in cultured cancer cells and a rat model of EMT6 colon tumors showed that fenbendazole has both cytotoxic and cytostatic activities at high drug concentrations, but at lower concentrations it is predominantly cytostatic. This overlapping profile suggests that the effects of fenbendazole are related to those of other hypoxia-selective nitroheterocyclic chemotherapeutic agents and may suggest that this class of compounds should be investigated further as potential anticancer agents.
Studies in mice with EMT6 tumors showed that fenbendazole significantly reduces both the growth rate of unirradiated tumors and the number of spontaneously occurring lung metastases found on necropsy when administered at high doses, but not at lower ones. These results confirm that fenbendazole has a cytostatic effect in these tumors, but that it is not as potent as other anticancer agents in this class, such as doxorubicin and vinca alkaloids. fenbendazole 222mg capsules for humans